In this uncertainty, the conclusion we may draw from the concomitant variations of a and A, to the existence of an invariable and exclusive connection between them, or to the permanency of the same numerical relation between their variations when the quantities are much greater or smaller than those which we have had the means of observing, can not be considered to rest on a complete induction. All that in such a case can be regarded as proved on the subject of causation is, that there is some connection between the two phenomena; that A, or something which can influence A, must be one of the causes which collectively determine a. We may, however, feel assured that the relation which we have observed to exist between the variations of A and a, will hold true in all cases which fall between the same extreme limits; that is, wherever the utmost increase or diminution in which the result has been found by observation to coincide with the law, is not exceeded.
The four methods which it has now been attempted to describe, are the only possible modes of experimental inquiry—of direct induction a posteriori, as distinguished from deduction: at least, I know not, nor am able to imagine any others. And even of these, the Method of Residues, as we have seen, is not independent of deduction; though, as it also requires specific experience, it may, without impropriety, be included among methods of direct observation and experiment.
These, then, with such assistance as can be obtained from Deduction, compose the available resources of the human mind for ascertaining the laws of the succession of phenomena. Before proceeding to point out certain circumstances by which the employment of these methods is subjected to an immense increase of complication and of difficulty, it is expedient to illustrate the use of the methods, by suitable examples drawn from actual physical investigations. These, accordingly, will form the subject of the succeeding chapter.
Chapter IX.
Miscellaneous Examples Of The Four Methods.
§ 1. I shall select, as a first example, an interesting speculation of one of the most eminent of theoretical chemists, Baron Liebig. The object in view is to ascertain the immediate cause of the death produced by metallic poisons.
Arsenious acid, and the salts of lead, bismuth, copper, and mercury, if introduced into the animal organism, except in the smallest doses, destroy life. These facts have long been known, as insulated truths of the lowest order of generalization; but it was reserved for Liebig, by an apt employment of the first two of our methods of experimental inquiry, to connect these truths together by a higher induction, pointing out what property, common to all these deleterious substances, is the really operating cause of their fatal effect.
When solutions of these substances are placed in sufficiently close contact with many animal products, albumen, milk, muscular fibre, and animal membranes, the acid or salt leaves the water in which it was dissolved, and enters into combination with the animal substance, which substance, after being thus acted upon, is found to have lost its tendency to spontaneous decomposition, or putrefaction.
Observation also shows, in cases where death has been produced by these poisons, that the parts of the body with which the poisonous substances have been brought into contact, do not afterward putrefy.
And, finally, when the poison has been supplied in too small a quantity to destroy life, eschars are produced, that is, certain superficial portions of the tissues are destroyed, which are afterward thrown off by the reparative process taking place in the healthy parts.
These three sets of instances admit of being treated according to the Method of Agreement. In all of them the metallic compounds are brought into contact with the substances which compose the human or animal body; and the instances do not seem to agree in any other circumstance. The remaining antecedents are as different, and even opposite, as they could possibly be made; for in some the animal substances exposed to the action of the poisons are in a state of life, in others only in a state of organization, in others not even in that. And what is the result which follows in all the cases? The conversion of the animal substance (by combination with the poison) into a chemical compound, held together by so powerful a force as to resist the subsequent action of the ordinary causes of decomposition. Now, organic life (the necessary condition of sensitive life) consisting in a continual state of decomposition and recomposition of the different organs and tissues, whatever incapacitates them for this decomposition destroys life. And thus the proximate cause of the death produced by this description of poisons is ascertained, as far as the Method of Agreement can ascertain it.
Let us now bring our conclusion to the test of the Method of Difference. Setting out from the cases already mentioned, in which the antecedent is the presence of substances forming with the tissues a compound incapable of putrefaction, (and a fortiori incapable of the chemical actions which constitute life), and the consequent is death, either of the whole organism, or of some portion of it; let us compare with these cases other cases, as much resembling them as possible, but in which that effect is not produced. And, first, “many insoluble basic salts of arsenious acid are known not to be poisonous. The substance called alkargen, discovered by Bunsen, which contains a very large quantity of arsenic, and approaches very closely in composition to the organic arsenious compounds found in the body, has not the slightest injurious action upon the organism.” Now when these substances are brought into contact with the tissues in any way, they do not combine with them; they do not arrest their progress to decomposition. As far, therefore, as these instances go, it appears that when the effect is absent, it is by reason of the absence of that antecedent which we had already good ground for considering as the proximate cause.
But the rigorous conditions of the Method of Difference are not yet satisfied; for we can not be sure that these unpoisonous bodies agree with the poisonous substances in every property, except the particular one of entering into a difficultly decomposable compound with the animal tissues. To render the method strictly applicable, we need an instance, not of a different substance, but of one of the very same substances, in circumstances which would prevent it from forming, with the tissues, the sort of compound in question; and then, if death does not follow, our case is made out. Now such instances are afforded by the antidotes to these poisons. For example, in case of poisoning by arsenious acid, if hydrated peroxide of iron is administered, the destructive agency is instantly checked. Now this peroxide is known to combine with the acid, and form a compound, which, being insoluble, can not act at all on animal tissues. So, again, sugar is a well-known antidote to poisoning by salts of copper; and sugar reduces those salts either into metallic copper, or into the red sub-oxide, neither of which enters into combination with animal matter. The disease called painter’s colic, so common in manufactories of white-lead, is unknown where the workmen are accustomed to take, as a preservative, sulphuric acid lemonade (a solution of sugar rendered acid by sulphuric acid). Now diluted sulphuric acid has the property of decomposing all compounds of lead with organic matter, or of preventing them from being formed.