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At the other end of the long table, two dozen white mice huddled and shivered in their cages. Occasionally one would break free to scurry and defecate in the sawdust, the sudden motion causing the bars to rattle and sing.

Through the lens, beads of fatty sweat stood out on a surface of tiny pits and pores. He held the point of a scalpel to each of these imperfections in turn, trying to get some sense of their scale. There was one point in particular where the chocolate dipped sharply, although when he looked at it without the magnifying glass the dip disappeared. Dr Pervoyedov located it again and pushed his scalpel into it. He then cut in the opposite direction.

The cream of the filling was pale brown, except for one area, now revealed in both sections of the chocolate, where a white powdery deposit, like the tail of a comet, could be seen. It was possible these were un-dissolved sugar particles; it was equally possible they were something else. He scooped some of the substance on to the end of his scalpel, which he dipped into a flask of distilled water. He allowed the extracted sample to dissolve, stirring the water with a glass rod. Finally he drew some of the water off with a pipette and pumped it into a feeding bottle, which he exchanged for the bottle on one of the cages.

The movement of his hand, and the noise of the metal clip as he put the water bottle in place, startled the mice into a mass convulsion. He saw the tiny rodents as bundles of living matter, life reduced to one of its purest and most meaningless forms. For what does a mouse live? he thought. Only for life itself.

But they were such timid creatures, shivering even in the heat of summer, dropping black slugs of faeces at the slightest disturbance of their precarious and reduced world. Even had these mice been in the wild, they would live out their lives in a narrow pattern of behaviour circumscribed by their habits and instincts, under the constant shadow of fear and more often than not racked by the ache of hunger. They reminded him of those peasants who never leave their village, not because they are forbidden by lack of passport, but because it would never occur to them to do so.

And yet this was life. He would even say it was one of the higher forms of life, compared with the twitching, seething organisms he saw under his microscope.

He did not do so now, but he had handled these mice many times. As he watched them, he cupped his hands and felt the remembered spasms of their weightless bodies, the sharpness of their fine claws against his skin, the nip of their teeth. He would always handle them reverently. He felt himself to be handling particles of life itself. The life force, the only thing he was capable of worshipping, pulsated in their fur and fear.

He watched as one of the mice came to sip at the water bottle. It moved away and cleaned its whiskers in a mechanistic reflex. Almost immediately, it returned to the water bottle for a second drink. No doubt it was the sugar in the water that drew it back. Again, this was followed by a burst of cleaning activity, more energetic and extended than the first, Pervoyedov judged. It was enough of a variation from the norm to pique his interest. Pervoyedov leant forward. As if in response, the mouse reared up on its hind legs and opened its mouth in a silent cry. Its pink eyes stood out wildly as it stretched its neck and rotated its head. He saw its throat go into spasm as the breaths came fast and sharp. Now the animal scrubbed at the side of its snout in what seemed like a desperate effort to remove its own face. It finally tucked its head down under its belly, so extremely that it flipped over on its back. The mouse quickly righted itself and began chasing its tail. Then it ran blindly into the side of the cage. After that it began to gnaw at its own forelimbs, drawing blood almost immediately. The mouse fell on to its side, though its legs continued moving, as if it believed it was still running. Before long, these movements became convulsive. There was a final shudder, then the creature was still.

Porfiry let out a small groan of dismay as he entered his chambers. The temperature was perhaps a degree or two higher than previous days, and the stench of sewage was more pungent than ever. The room gave him nothing to breathe. He felt immediately exhausted and nauseous. He swatted a hand vaguely, prompted by the enquiring buzz of a bluebottle circling his head. He saw it fly in an erratic swooping zigzag over to the window, where it rattled uselessly after hitting the glass with an audible pop.

Virginsky followed him in. ‘Shall I open a window, Porfiry Petrovich?’

‘Yes, yes. See if you can get rid of that fly.’ Porfiry took a seat behind his desk, then immediately stood up, pushing the chair away impatiently. In front of him was a large yellow envelope with his name handwritten on it. Porfiry lit a cigarette before turning his attention to it.

Virginsky opened the window to release the fly. The atmosphere in the room worsened perceptibly.

‘Close it!’ cried Porfiry. He took out a sheaf of official form papers clipped together, which he recognised as a medical examiner’s report. A small note, the handwriting matching that of the envelope, fell out with them.

His Excellency, The Honoured and Esteemed Magistrate Porfiry Petrovich,

Allow me to present for your attention my findings regarding the substances that you had delivered to me for analysis. As you will see from the document enclosed, it is impossibleto identify with absolute certainty the toxic agent responsible for killing the two bodies examined by my esteemed colleague Dr Feuerbach, although a number of candidate substances for which there are currently reliable tests, to wit, arsenic, prussic acid, etc., have been eliminated. However, it has been possible to establish the method of administration of the toxic agent. A small quantity taken from the remaining Ballet’s chocolate induced death in a sample of mice; the peculiar symptoms suffered by these mice were replicated in other test groups when distillations taken from the victims’ stomach contents were administered. The same results were achieved with distillations from the vomit recovered from the scene of death. In the interests of providing a juridically acceptable identification, by means of experimentation rather than analysis, a number of known poisons were then administered to further samples of mice, and the reactions monitored. One substance produced manifestations which corresponded exactly to the results provided by the remaining Ballet’s chocolate, stomach contents and vomit: aconite. It is the opinion, therefore, of this medical examiner that the deaths of Raisa Ivanovna Meyer and Grigory Martinovich Meyer were caused by aconite poisoning, administered by means of a contaminated box of chocolates. The full scientific reasons for this opinion are given in the enclosed report.

I would like, if I may, to add one personal note. I have known Martin Meyer for a number of years, both in a professional and personal capacity. I will only say that I do not believe him capable of murdering his wife and son. This belief, and indeed my declared association with Martin Meyer, is not pertinent to my medical opinion, and should have no bearing on it.

Your humble servant,

Dr P. P. Pervoyedov.

‘The idiot!’ Porfiry threw the letter down, disturbing two flies that were crawling on his desk.

Virginsky snatched the note and scanned it.

Still standing over his desk, Porfiry riffled through the pages of the report impatiently. ‘This is useless. A clever defence lawyer will argue it is inadmissible, because of Pervoyedov’s relationship with Meyer.’