2. Angelman, H. (1965). 'Puppet' children. Developmental Medicine and Child Neurology 7: 681—8.
3. McGrath, J. and Solter, D. (1984). Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 37: 179—83; Barton, S. C, Surami, M. A. H. and Norris, M. L. (1984). Role of paternal and maternal genomes in mouse development. Nature 311: 374—6.
4. Haig, D. and Westoby, M. (1989). Parent-specific gene expression and the triploid endosperm. American Naturalist 134: 147—55.
5. Haig, D. and Graham, C. (1991). Genomic imprinting and the strange case of the insulin-like growth factor II receptor. Cell 64: 1045—6.
6. Dawson, W. (1965). Fertility and size inheritance in a Peromyscus species cross. Evolution 19: 44—5 5; Mestel, R. (1998). The genetic battle of the sexes.
Natural History 107: 44—9.
7. Hurst, L. D. and McVean, G. T. (1997). Growth effects of uniparental disomies and the conflict theory of genomic imprinting. Trends in Genetics 13: 436—43; Hurst, L. D. (1997). Evolutionary theories of genomic imprinting. In Reik, W. and Surani, A. (eds), Genomic imprinting, pp. 211-37. Oxford University Press, Oxford.
8. Horsthemke, B. (1997). Imprinting in the Prader-Willi/Angelman syndrome region on human chromosome 15. In Reik, W. and Surani, A. (eds), Genomic imprinting, pp. 177-90. Oxford University Press, Oxford.
9. Reik, W. and Constancia, M. (1997). Making sense or antisense? Nature 389: 669—71.
10. McGrath, J. and Solter, D. (1984). Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 37: 179-83.
11. Jaenisch, R. (1997). DNA methylation and imprinting: why bother?
Trends in Genetics 13: 323—9.
12. Cassidy, S. B. (1995). Uniparental disomy and genomic imprinting as causes of human genetic disease. Environmental and Molecular Mutagenesis 25, Suppl. 26: 13-20; Kishino, T. and Wagstaff, J. (1998). Genomic organisation of the UBE3A/E6-AP gene and related pseudogenes. Genomics 47: 101—7.
13. Jiang, Y., Tsai, T.-F., Bressler, J. and Beaudet, A. L. (1998). Imprinting in Angelman and Prader-Willi syndromes. Current Opinion in Genetics and Development 8: 334—42.
14. Allen, N. D., Logan, K., Lally, G., Drage, D. J., Norris, M. and Keverne, B I B L I O G R A P H Y A N D N O T E S 3 3 1
E. B. (1995). Distribution of pathenogenetic cells in the mouse brain and their influence on brain development and behaviour. Proceedings of the National Academy of Sciences of the USA 92: 10782—6; Trivers, R. and Burt, A. (in preparation), Kinship and genomic imprinting.
15. Vines, G. (1997). Where did you get your brains? New Scientist, 3 May 1997: 34-9; Lefebvre, L., Viville, S., Barton, S. C, Ishino, F., Keverne, E. B. and Surani, M. A. (1998). Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nature Genetics 20: 163—9.
16. Pagel, M. (1999). Mother and father in surprise genetic agreement. Nature 397: 19-20.
17. Skuse, D. H. et al. (1997). Evidence from Turner's syndrome of an imprinted locus affecting cognitive function. Nature 387: 705—8.
18. Diamond, M. and Sigmundson, H. K. (1997). Sex assignment at birth: long-term review and clinical implications. Archives of Pediatric and Adolescent Medicine 151: 298-304.
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There are no good popular books on the genetics of learning mechanisms.
A good textbook is: M. F. Bear, B. W. Connors and M. A. Paradiso's Neuroscience: exploring the brain (Williams and Wilkins, 1996).
1. Baldwin, J. M. (1896). A new factor in evolution. American Naturalist 30: 441-51, 536-53.
2. Schacher, S., Castelluci, V. F. and Kandel, E. R. (1988). cAMP evokes long-term facilitation in Aplysia neurons that requires new protein synthesis.
Science 240: 1667—9.
3. Bailey, C. H., Bartsch, D. and Kandel, E. R. (1996). Towards a molecular definition of long-term memory storage. Proceedings of the National Academy of Sciences of the USA 93: 12445 — 52.
4. Tully, T., Preat, T., Boynton, S. C. and Del Vecchio, M. (1994). Genetic dissection of consolidated memory in Drosophila. Cell 79: 39-47; Dubnau, J. and Tully, T. (1998). Gene discovery in Drosophila: new insights for learning and memory. Annual Review of Neuroscience 21: 407—44.
5. Silva, A. J., Smith, A. M. and Giese, K. P. (1997). Gene targeting and 3 3 2 G E N O M E
the biology of learning and memory. Annual Review of Genetics 31: 527—46.
6. Davis, R. L. (1993). Mushroom bodies and Drosophila learning.
Neuron 11: 1-14; Grotewiel, M. S., Beck, C. D. O., Wu, K. H., Zhu, X.-R.
and Davis, R. L. (1998). Integrin-mediated short-term memory in Drosophila.
Nature 391: 455—60.
7. Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., Van-Paesschen, W. and Mishkin, M. (1997). Differential effects of early hippo¬
campal pathology on episodic and semantic memory. Science 277: 376—80.
C H R O M O S O M E 1 7
The best recent account of cancer research is Robert Weinberg's One renegade cell (Weidenfeld and Nicolson, 1998).
1. Hakem, R. et al. (1998). Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339—52.
2. Ridley, M. (1996). The origins of virtue. Viking, London; Raff, M. (1998).
Cell suicide for beginners. Nature 396: 119-22.
3. Cookson, W. (1994). The gene hunters: adventures in the genome jungle. Aurum Press, London.
4. Sunday Telegraph, 3 May 1998, p. 25.
5. Weinberg, R. (1998). One renegade cell. Weidenfeld and Nicolson, London.
6. Levine, A. J. (1997). P53, the cellular gatekeeper for growth and division.
Cell 88: 323-31.
7. Lowe, S. W. (1995). Cancer therapy and p53. Current Opinion in Oncology 7: 547-53.
8. Huber, A . O . and Evan, G. I. (1998). Traps to catch unwary oncogenes.
Trends in Genetics 14: 364—7.
9. Cook-Deegan, R. (1994). The gene wars: science, politics and the human genome.
W. W. Norton, New York.
10. Krakauer, D. C. and Payne, R. J. H. (1997). The evolution of virus-induced apoptosis. Proceedings of the Royal Society of London, Series B 264: 1757-62.
11.. Le Grand, E. K. (1997). An adaptationist view of apoptosis. Quarterly Review of Biology 72: 135—47.
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C H R O M O S O M E 1 8
Geoff Lyon and Peter G o r n e r ' s blow-by-blow account of the development of gene therapy, Altered fates ( N o r t o n , 1996) is a g o o d place to start. Eat your genes by Stephen Nottingham (Zed Books, 1998) details the history of plant genetic engineering. Lee Silver's Remaking Eden (Weidenfeld and Nicolson, 1997) explores the implications of reproductive technologies and genetic engineering in h u m a n beings.