Being eager to get away from the country, the Spaniards laboured indefatigably in fitting out the vessels, even the best gentlemen among them using the utmost diligence; while those who were not handy in the several occupations about the brigantines employed themselves in hunting and fishing to procure provisions for the rest. Among other fish taken on the present occasion, one was taken by means of a hook of such enormous dimensions, that the head alone weighed forty pounds. The confederate Indians under Quiqualtanqui continued their warlike preparations, being much encouraged by knowing that Ferdinand de Soto was dead, that the number of the Spaniards was very much diminished, and that very few horses were left. So confident were they of success, that two of their spies desired some of the Indian women who served the Spaniards to be patient, for they would soon be freed from their bondage to these vagabond robbers, as they were all to be slain. But the women disclosed this to their masters. When the night happened to be very still, the noise of many people could be heard from the opposite side of the river; and the Spaniards could distinctly see numerous fires at regular distances, as of the quarters of a large army. But it pleased God to confound the evil designs of these Indians, by an inundation of the river, which began on the 10th of March 1543, and increased with prodigious rapidity, so that on the 18th which was Palm Sunday, when the Spaniards were in procession, for they observed all the religious solemnities, the water broke in at the gates of the town, and there was no going along the streets for long after but in canoes. This inundation was forty days of rising to its greatest height, which was on the 20th of April, at which time it extended above twenty leagues on each side of the river, so that nothing could be seen in all the country around but the tops of the trees, and the people had to go every where in canoes.
During the time of this terrible inundation, Alvarado sent twenty Spaniards to Anilco to request a supply of rosin, blankets, and cordage for completing the equipment of the vessels, and these men were sent in four canoes lashed two and two together, to prevent them from being overset by the trees which were under water. On coming to the town of Anilco, they found it destroyed, though twenty leagues from the Spanish quarters, and the inundation had extended five leagues farther. Gonzado Silvestre who commanded these Spaniards was greatly in favour of the cacique Anilco, because he had restored to him a youth who had accompanied the Spaniards on their march to the westwards, who perfectly understood the Spanish language, and was so much attached to the Spaniards as to be very averse from returning to his father. On this occasion Anilco supplied Silvestre with every thing of which he was in want.
It pleased God that the water began to subside towards the latter end of April; yet so slowly that on the 10th of May there was no going about the streets of the town on account of the deep mire with which they were filled. This was the more distressing to the Spaniards as they were barefooted, all their shoes having been burnt at Mavila, and the shoes they had since been able to make, being of untanned leather, were like so much tripe as soon as wet. At the latter end of May, the great river returned to its usual channel, and the confederated Indians again drew their forces together to execute their original design against the Spaniards, of which they received intelligence from Anilco; who likewise informed Alvarado of the signals which had been concerted by the confederates for the better prosecution of their enterprise, and even offered to assist the Spaniards with 8000 well armed warriors, and that if they chose to retire into his country the confederates would not dare to attack them. Alvarado returned thanks for these friendly offers, but declined accepting them; because as he intended to go down the river and to quit the country, he did not deem it proper either to take refuge in the territory of Anilco or to accept the assistance of his warriors, as either of those might draw upon him the confederated hostility of his neighbours: But he promised, if it should please God ever to put it in his power, Anilco should not have cause to repent the service he had been of to the king of Spain, or the kindness he had shewn to the Spaniards. In conclusion, he recommended to Anilco to discontinue any farther intercourse with him, lest he might give umbrage to the confederated caciques. Many of the Spaniards were so puffed up by the friendly offers of Anilco, that they endeavoured to persuade Alvarado to accept the proferred aid, and prosecute an offensive war, thinking it easy to subdue these people. But Alvarado was quite sensible of his present weakness, and determined to leave the country as soon as possible; besides which he did not deem it prudent to confide too much on the fidelity of Anilco.
Four days afterwards, exactly conformable to the information received from Anilco, a numerous embassy arrived from the confederated caciques, intended to spy out the posture of the Spaniards, to enable them to concert measures for the intended attack. Having rigidly examined these pretended messengers, it was debated among the leaders of the Spaniards what ought to be done with these fraudulent envoys. Some were for giving them fair words, as had been the practice hitherto; but it was finally resolved to punish them in an exemplary manner, that the caciques might know their treachery was discovered, which might perhaps prevent the execution of their designs. Accordingly though the messengers on this occasion were very numerous, thirty only were selected who had their hands cut off, and were sent back in this guise to their employers, with a message signifying that the Spaniards had all along been aware of their villainy. This severe example proved successful, insomuch that the confederacy was immediately dissolved, and the forces retired to their respective countries. Yet as the Spaniards had only built seven great boats, they thought they might possibly be more successful by water, and they agreed to collect a great number of canoes to attack them while going down the river.
As the Spaniards believed that their only safety depended upon going down the river as soon as possible, they hastened the completion of their vessels; and as they had not enough of iron for the construction of whole decks, they satisfied themselves with quarter-decks and fore-castles to secure the provisions, laying planks only a midships. Every thing relative to the brigantines being completed, they gathered all the Indian corn, pulse, and dried fruit they could procure; made bacon of all the swine that were left alive, except eighteen they carried with them alive, and two boars and two sows which they gave to each of the two caciques who were their friends. With the lard of the slaughtered swine, they tempered rosin instead of pitch and tar for paying their vessels. They likewise provided a number of canoes; part of which were lashed two and two together to carry thirty horses which still remained alive, and answered well for the purpose; the rest were distributed among the brigantines, each having one at her stern to serve as a boat. On midsummer day 1543 the brigantines were launched into the great river, and on St Peters day, the 29th of that month, every thing being in readiness, the brigantines and canoes having defences made of boards and skins to fend off the arrows, they took leave of the friendly caciques, Anilco and Guachacoya, and set sail down the great river.
Two captains were appointed to each brigantine, that when one had occasion to land the other might remain on board in charge of the vessel. About 350 Spaniards embarked, all that remained of 900 who had originally landed in Florida. Near thirty Indian men and women were on board each vessel, all of their own free will, as they declared they would rather die with their masters than remain behind. Accordingly on St Peters day before mentioned, about sunset, after Alvarado had given regular instructions to all his officers and encouraged his men, they began their voyage, holding on their course down the river both with sails and oars, all that night and the next day and night. But on the following day they were opposed by a fleet of near 1000 canoes belonging to the confederated caciques, some of which were so large as to have twenty-five paddies on each side, and carrying many armed men besides the rowers. These large canoes were called the admirals, as being supposed to have the principal commanders on board. One was painted red, another blue, and others of several colours; the men on board having their bodies painted of the same colours as the canoes, as were their bows. All this splendid shew, with the variegated plumes of feathers on the heads of the warriors, made a grand display. While they rowed after the Spaniards, they kept time to their songs, which were said by the interpreters to signify, "That the vagabond strangers should all be slain on the water, and become food for the fishes."