§ 6. We have now to consider according to what method these complex effects, compounded of the effects of many causes, are to be studied; how we are enabled to trace each effect to the concurrence of causes in which it originated, and ascertain the conditions of its recurrence—the circumstances in which it may be expected again to occur. The conditions of a phenomenon which arises from a composition of causes, may be investigated either deductively or experimentally.
The case, it is evident, is naturally susceptible of the deductive mode of investigation. The law of an effect of this description is a result of the laws of the separate causes on the combination of which it depends, and is, therefore, in itself capable of being deduced from these laws. This is called the method a priori. The other, or a posteriori method, professes to proceed according to the canons of experimental inquiry. Considering the whole assemblage of concurrent causes which produced the phenomenon, as one single cause, it attempts to ascertain the cause in the ordinary manner, by a comparison of instances. This second method subdivides itself into two different varieties. If it merely collates instances of the effect, it is a method of pure observation. If it operates upon the causes, and tries different combinations of them, in hopes of ultimately hitting the precise combination which will produce the given total effect, it is a method of experiment.
In order more completely to clear up the nature of each of these three methods, and determine which of them deserves the preference, it will be expedient (conformably to a favorite maxim of Lord Chancellor Eldon, to which, though it has often incurred philosophical ridicule, a deeper philosophy will not refuse its sanction) to “clothe them in circumstances.” We shall select for this purpose a case which as yet furnishes no very brilliant example of the success of any of the three methods, but which is all the more suited to illustrate the difficulties inherent in them. Let the subject of inquiry be, the conditions of health and disease in the human body; or (for greater simplicity) the conditions of recovery from a given disease; and in order to narrow the question still more, let it be limited, in the first instance, to this one inquiry: Is, or is not, some particular medicament (mercury, for instance) a remedy for the given disease.
Now, the deductive method would set out from known properties of mercury, and known laws of the human body, and by reasoning from these, would attempt to discover whether mercury will act upon the body when in the morbid condition supposed, in such a manner as would tend to restore health. The experimental method would simply administer mercury in as many cases as possible, noting the age, sex, temperament, and other peculiarities of bodily constitution, the particular form or variety of the disease, the particular stage of its progress, etc., remarking in which of these cases it was attended with a salutary effect, and with what circumstances it was on those occasions combined. The method of simple observation would compare instances of recovery, to find whether they agreed in having been preceded by the administration of mercury; or would compare instances of recovery with instances of failure, to find cases which, agreeing in all other respects, differed only in the fact that mercury had been administered, or that it had not.
§ 7. That the last of these three modes of investigation is applicable to the case, no one has ever seriously contended. No conclusions of value on a subject of such intricacy ever were obtained in that way. The utmost that could result would be a vague general impression for or against the efficacy of mercury, of no avail for guidance unless confirmed by one of the other two methods. Not that the results, which this method strives to obtain, would not be of the utmost possible value if they could be obtained. If all the cases of recovery which presented themselves, in an examination extending to a great number of instances, were cases in which mercury had been administered, we might generalize with confidence from this experience, and should have obtained a conclusion of real value. But no such basis for generalization can we, in a case of this description, hope to obtain. The reason is that which we have spoken of as constituting the characteristic imperfection of the Method of Agreement, Plurality of Causes. Supposing even that mercury does tend to cure the disease, so many other causes, both natural and artificial, also tend to cure it, that there are sure to be abundant instances of recovery in which mercury has not been administered, unless, indeed, the practice be to administer it in all cases; on which supposition it will equally be found in the cases of failure.
When an effect results from the union of many causes, the share which each has in the determination of the effect can not in general be great, and the effect is not likely, even in its presence or absence, still less in its variations, to follow, even approximately, any one of the causes. Recovery from a disease is an event to which, in every case, many influences must concur. Mercury may be one such influence; but from the very fact that there are many other such, it will necessarily happen that although mercury is administered, the patient, for want of other concurring influences, will often not recover, and that he often will recover when it is not administered, the other favorable influences being sufficiently powerful without it. Neither, therefore, will the instances of recovery agree in the administration of mercury, nor will the instances of failure agree in its non-administration. It is much if, by multiplied and accurate returns from hospitals and the like, we can collect that there are rather more recoveries and rather fewer failures when mercury is administered than when it is not; a result of very secondary value even as a guide to practice, and almost worthless as a contribution to the theory of the subject.[150]
§ 8. The inapplicability of the method of simple observation to ascertain the conditions of effects dependent on many concurring causes, being thus recognized, we shall next inquire whether any greater benefit can be expected from the other branch of the a posteriori method, that which proceeds by directly trying different combinations of causes, either artificially produced or found in nature, and taking notice what is their effect; as, for example, by actually trying the effect of mercury in as many different circumstances as possible. This method differs from the one which we have just examined in turning our attention directly to the causes or agents, instead of turning it to the effect, recovery from the disease. And since, as a general rule, the effects of causes are far more accessible to our study than the causes of effects, it is natural to think that this method has a much better chance of proving successful than the former.
150
It is justly remarked by Professor Bain, that though the Methods of Agreement and Difference are not applicable to these cases, they are not wholly inaccessible to the Method of Concomitant Variations. “If a cause happens to vary alone, the effect will also vary alone: a cause and effect may be thus singled out under the greatest complications. Thus, when the appetite for food increases with the cold, we have a strong evidence of connection between these two facts, although other circumstances may operate in the same direction. The assigning of the respective parts of the sun and moon in the action of the tides may be effected, to a certain degree of exactness, by the variations of the amount according to the positions of the two attractive bodies. By a series of experiments of Concomitant Variations, directed to ascertain the elimination of nitrogen from the human body under varieties of muscular exercise, Dr. Parkes obtained the remarkable conclusion, that a muscle grows during exercise, and loses bulk during the subsequent rest.” (
It is, no doubt, often possible to single out the influencing causes from among a great number of mere concomitants, by noting what are the antecedents, a variation in which is followed by a variation in the effect. But when there are many influencing causes, no one of them greatly predominating over the rest, and especially when some of these are continually changing, it is scarcely ever possible to trace such a relation between the variations of the effect and those of any one cause as would enable us to assign to that cause its real share in the production of the effect.